Integrins modulate the infection efficiency of West Nile virus
West Nile virus (WNV) is a small, enveloped, single-stranded RNA virus in the family Flaviviridae. In the natural transmission cycle WNV circulates between mosquitoes as vectors and birds as reservoir hosts. WNV can infect a wide taxonomical range of vertebrate species but most of them do not sufficiently support virus replication for transmission. Disease symptoms rarely occur, except in humans and horses where WNV infections are frequently accompanied by a mild fever (West Nile fever), which occasionally results in the development of neurological disorders with fatal outcome.
The cellular receptors and determinants that mediate entry of WNV are unclear to date. The notable ability of WNV to infect a broad range of species (mosquitoes, reptiles, birds and mammals), and virtually every in vitro cell line is supposed to be related to cellular proteins, relevant for virus entry and replication, which are highly conserved among divergent host species.
By using integrin knock-out cell lines which lack the particular integrin subunits, this study demonstrate that the presence of αv-, β1- or β3-integrins is not required for the attachment of four different WNV strains to the cell surface.
Gonna quickly throw in an epic quote I found on this article.
KJKJ: Gene Roddenberry, with balls of brass, got up on national tv and said, “hey people, if a geneticist took all the best DNA from planet Earth and put it together to make the best human the world has ever seen - he wouldn’t be a white guy.”
This is why I find the casting of a white actor in this role to be so repugnant. They are not whitewashing an Asian role, they are saying that the best genetic material that the entirety of this world and it’s diversity has to offer….still comes from a white guy.
Reblogging again for that
Happy Mother’s Day to all the mothers out there and thank you for all you do, starting with the creation of life through gestation. We all begin as an embryo, and life only gets better when we leave the womb and get to meet the woman who brought us forth. The word embryo comes into English in the mid 14th century fully formed from the Ancient Greek word embryon (εμβρυον) meaning a young one. In earlier Greek (specifically Homer) embryon meant a young animal and acquired the poetic use of fruit of the womb, a compound word composed of the prefix en and the root bryein (βρυειν) meaning to swell or be full.
Image of an embryo courtesy lunar caustic, used with permission under a creative commons 3.0 license.
I don’t understand, and I am frightened by things I don’t understand.
Actually, this is very simple to understand. This device is one of the most remarkable developments of technology I have ever seen. You may see as something goofy or creepy, and yeah, it might look like it, but this robot was created to carry supplies and equipment that weigh hundreds of pounds for scientists who can’t easily carry all that themselves, even with dollies or carts.
You see the snow and ice in the background? The robot is carrying all that weight in a snowy climate for some scientists. It stumbles and slips on the ice, but then it rights itself. Every time it’s just about to fall, it criss-crosses its legs and catches itself whereas someone like me would fall flat on his/her face. This robot is an outstanding AI model. It calculates where it is slipping and figures out exactly how to get back up.
Yeah it’s outstanding but god damn I can’t stop laughing at it jesus christ that’s hilarious look at it it nearly falls for like five whole seconds and I just can’t
A) This is not meant for scientists. This is meant for the military. This is Big Dog. (curtesy of DARPA)
Nucleotide G at SNP rs 7646919 has been associated with ASD [source]. The SNP is a silent mutation in NLGN1 [neuroligin-1] — that encodes for a cell-adhesion molecule located at the post-synaptic side of the synapse.
Ever wonder how neurons stay so close together? Tight spaces helps make the most of chemical signaling.